Wolff-Parkinson-White Syndrome (SWPW) is a congenital syndrome that results from the presence of additional electrical pathways in the heart’s electrical conduction system.

About 40% of people never develop symptoms. In those who develop symptoms, the most common are elevated heart rate, palpitations, shortness of breath, feeling faint, and loss of consciousness. In rare cases cardiac arrest may occur. The most common type of cardiac arrhythmia caused by SWPW is paroxysmal supraventricular tachycardia.

In most cases, the exact causes are not known. A small percentage originates from a mutation in the PRKAG2 gene, which can be inherited from one of the parents in an autosomal dominant manner. The underlying mechanism involves the presence of accessory pathways between the atria and ventricles of the heart, which causes electrical conduction to occur beyond the normal conduction system, affecting the cardiac cycle. The syndrome is associated with other conditions, such as Ebstein’s anomaly and hypokalemic periodic paralysis. The diagnosis is usually confirmed with an electrocardiogram in which a short PR interval and the presence of a delta wave are observed. SWPS is a type of pre-arousal syndrome.

This video I do not own. I put here just for learning purposes.

Treatment usually consists of drug administration or radiofrequency catheter ablation. The condition affects between 0.1 and 0.3% of the population. In people who do not have symptoms, the risk of death per year is about 0.5% in children and 0.1% in adults. In people without symptoms, surveillance of the condition may be sufficient. In people in whom SWPW is complicated by the presence of atrial fibrillation, cardioversion or administration of procainamide may be necessary. The condition is named after Louis Wolff, John Parkinson and Paul Dudley White, who in 1930 were the first to describe the findings on the electrocardiogram.

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